A joint course with the CUSO Doctoral Program in Ecology & Evolution

Organisers:

• Prof. Jérôme Goudet, University of Lausanne (CH) & Swiss Institute of Bioinformatics
• Prof. Bruce Weir, University of Washington (USA)

Venue: University of Lausanne

A unified treatment for the analysis of discrete genetic data, starting with estimates and sample variances of allele frequencies to illustrate genetic vs statistical sampling and Bayesian approaches.

A detailed look at Hardy-Weinberg and linkage disequilibrium, including the use of exact tests with mid-p-values and a new look at X-chromosome Hardy- Weinberg testing.

A new characterization of population structure with F-statistics, based on allelic matching within and between populations with individual relationship estimation as a special case.

Analyses illustrated with applications to forensic science and association mapping, with particular reference to rare variants.

Concepts illustrated with R exercises.

Background reading: Holsinger, K. and B.S. Weir. 2009. Genetics in geographically structured populations:defining, estimating, and interpreting Fst. Nature Reviews Genetics 10:639--650.

Weir, B.S. and C.C. Laurie. 2011. Statistical genetics in the genome era. Genetics Research 92:461--470.

• Prof. Jérôme Goudet, University of Lausanne (CH) & Swiss Institute of Bioinformatics
• Prof. Bruce Weir, University of Washington (USA)

Date: 6 September (afternoon) & 7 - 8 September (all days) (2,5 days)

Schedule: 9.00-12.00 and 13.30-17.30

Venue:  University of Lausanne, room to be announced

ECTS: 1.5 (Research tools)

Evaluation: Full attendance and active participation

Information: Please contact the CUSO E&E doctoral program coordinator Caroline Betto-Colliard @: ecologie-evolution@cuso.ch, phone: +41 (0)21 692 42 44

• Please bring your laptop to the course!

Registration fee: Free for participants belonging to a CUSO University (UniBE, UniFR, UniGE, UniL & UniNE) and PhD students of the DP-biol

Travel expenses: For participants of the Interuniversity doctoral program in organismal biology (DP-biol ): see reimbursement conditions

For participants of the CUSO doctoral program in Ecology and Evolution: see CUSO E&E web site

MAKE SURE you SIGN the ATTENDANCE LIST EACH and EVERY DAY and TAKE your ATTESTATION of ATTENDANCE at the END of the COURSE (no attestation will be sent by mail)

!PREREQUISITE! Have attended the course "An Introduction to R" or a similar course.

Registration through the CUSO Doctoral Program in Ecology and Evolution web site closed